Trajenta Diabetes, a medication used to treat type 2 diabetes, has a long elimination half-life. This means that the body need a large amount of time to eliminate the medicine from its system. Trajenta's elimination half-life is approximately 155 hours*or 6.4 days. This means that the body may take up to 6.4 days to clear half of the medicine from its system. The remaining half of the medicine will require another 6.4 days to be eliminated, and so on. This prolonged elimination half-life can result in a medication's longer duration of effect, which can be useful for blood sugar management. However, it also means that the body may take longer to eliminate the medication from the system, which should be considered when discontinuing the prescription or moving to a different treatment.